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Published on: July 19, 2018
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Hyaluronan reduces colitis-induced intraperitoneal inflammation during peritoneal dialysis
Jasiński Tomasz1, Bręborowicz Andrzej2
1Department of Large Animal Diseases, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Poland.
Summary
Acute colitis exacerbates peritoneal inflammation during dialysis in rats, potentially accelerating peritoneal damage. Hyaluronan supplementation in dialysis fluid can mitigate this heightened inflammatory response.
Area of Science:
- Nephrology
- Gastroenterology
- Inflammation Research
Background:
- Peritoneal dialysis (PD) can trigger peritoneal inflammation, leading to progressive peritoneal membrane damage.
- The proximity of the intestines suggests that visceral disorders, like colitis, may influence intraperitoneal inflammation during PD.
Purpose of the Study:
- To investigate the impact of acute colitis on intraperitoneal inflammation in rats undergoing PD.
- To evaluate the potential protective effects of hyaluronan in this context.
Main Methods:
- Rats with dextran sulfate-induced colitis underwent 6-hour PD using standard fluid with or without hyaluronan.
- Control rats without colitis were also studied.
- Peritoneal permeability and inflammatory markers in dialysate were assessed post-PD.
Main Results:
- Colitis significantly increased intraperitoneal inflammation, evidenced by higher dialysate cell counts, neutrophils, free radicals, elastase, TNF-α, and MCP-1.
- Rats with colitis showed reduced drained dialysate volume and increased peritoneal permeability.
- Hyaluronan supplementation in PD fluid reduced the intensity of inflammation.
Conclusions:
- Visceral inflammation from colitis intensifies peritoneal inflammation during PD, potentially accelerating peritoneal damage.
- Supplementing PD fluid with hyaluronan effectively reduces this inflammation.
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