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[Cardiac Involvement in COVID-19]

A B Sugraliyev1

  • 1Kazakh National Medical University, Almaty, Kazakhstan.

Kardiologiia
|May 17, 2021
PubMed

Insights

COVID-19, a severe respiratory illness, can cause significant heart damage. This review examines the role of the angiotensin-converting enzyme 2 receptor and its impact on cardiovascular complications in COVID-19 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • COVID-19 is a contagious disease causing severe respiratory distress and thrombo-inflammation.
  • Cardiac complications are increasingly reported in severe and critical COVID-19 cases.
  • The angiotensin-converting enzyme 2 (ACE2) receptor is implicated in viral entry and pathogenesis.

Purpose of the Study:

  • To review the role of ACE2 in viral entry.
  • To describe cardiac and coronary artery damage in COVID-19.
  • To assess the impact of hypertension and ACE2 inhibitors on COVID-19 patient prognosis.

Main Methods:

  • Literature review of studies on COVID-19 and cardiovascular effects.
  • Analysis of the mechanism of viral entry via ACE2.
  • Examination of clinical data regarding cardiac damage and comorbidities.

Main Results:

  • ACE2 receptor is crucial for SARS-CoV-2 entry into host cells.
  • COVID-19 is associated with diverse cardiac pathologies, including myocarditis and coronary artery issues.
  • Arterial hypertension and use of renin-angiotensin-aldosterone system inhibitors influence COVID-19 outcomes.

Conclusions:

  • ACE2 plays a central role in COVID-19 pathogenesis and cardiac involvement.
  • Understanding these mechanisms is vital for managing COVID-19 patients with cardiovascular risks.
  • Further research is needed to clarify the long-term cardiovascular consequences and optimal treatment strategies.

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