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[Expert consensus regarding treatment of iron deficiency in stable and decompensated patients with heart failure]

Yu V Mareev1, S R Gilarevsky2, Yu L Begrambekova3

  • 1National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow, Great Britain.

Kardiologiia
|May 17, 2021
PubMed

Insights

Treating iron deficiency (ID) in heart failure (HF) patients with intravenous ferric carboxymaltose is recommended. This therapy reduces future hospitalizations for acute decompensation and improves quality of life in stable HF patients.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Iron deficiency (ID) is prevalent in heart failure (HF) patients, negatively impacting outcomes.
  • Intravenous ferric carboxymaltose is the sole proven therapy for ID in HF, according to 2020 Russian HF guidelines.

Purpose of the Study:

  • To evaluate the impact of treating ID in acute HF decompensation.
  • To inform clinical practice regarding ID screening and treatment in HF patients.

Main Methods:

  • Analysis of data from the AFFIRM-AHF trial.
  • Expert consensus on treatment recommendations.

Main Results:

  • Treatment of ID with intravenous ferric carboxymaltose post-acute HF decompensation reduces future HF hospitalizations.
  • Patients with stable HF may experience improved quality of life and symptom relief with ID treatment.

Conclusions:

  • Screening for and treating ID in HF patients is clinically reasonable.
  • Intravenous ferric carboxymaltose is effective for reducing HF hospitalizations in specific patient subgroups.

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