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Management of life-threatening flecainide overdose: a case report of an infant

T Tuncer1

  • 1Department of Pediatrics, Division of Pediatric Cardiology, Saglik Bilimleri University, Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey.

Cardiology in the Young
|May 17, 2021
PubMed

Insights

Flecainide overdose is dangerous, especially in infants, due to slow drug elimination. This case highlights challenges in managing prolonged toxicity from fetal and neonatal exposure.

Area of Science:

  • Clinical Toxicology
  • Pediatric Pharmacology
  • Cardiology

Background:

  • Flecainide overdose presents significant management challenges due to its pharmacokinetic properties.
  • High mortality rates underscore the need for effective treatment strategies.

Observation:

  • A life-threatening flecainide overdose in an infant is described.
  • The infant experienced a prolonged toxic course due to prenatal and neonatal drug exposure.

Findings:

  • Management of severe flecainide toxicity in neonates is complex.
  • Extended drug elimination necessitates prolonged monitoring and supportive care.

Implications:

  • This case emphasizes the critical importance of careful medication management during pregnancy and infancy.
  • Understanding flecainide's pharmacokinetics is vital for managing overdose in vulnerable populations.
  • Highlights the need for specialized pediatric toxicology protocols for antiarrhythmic overdoses.

Keywords:
Flecainide overdoseflecainide intoxicationinfant

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