Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Aneurysm I: Introduction

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Severity of COVID-19 cases in the months of predominance of the Alpha and Delta variants.

Scientific reports·2022

Same author

[Potentially inappropriate prescribing: Usefulness of STOPP/START criteria version 2 in Catalonian elderly population].

Semergen·2022

Same author

Guidelines on controlling latent tuberculosis infection to support tuberculosis elimination.

Revista espanola de sanidad penitenciaria·2021

Same author

Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells.

EXCLI journal·2020

Same author

Risk factors and comorbidities associated with severe aortic stenosis: a case-control study.

Revista clinica espanola·2020

Same author

[The Spain profile of measles: Cases in adults, imported-related and associated to health care].

Semergen·2020

Search research articles

Related Experiment Video

Updated: Nov 5, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Risk factors and comorbidities associated with severe aortic stenosis: A case-control study.

J M Gracia Baena¹, I Calaf Vall², M Zielonka²

¹Servei de Cirurgia Cardíaca d'Adults, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Unitat d'Epidemiologia Aplicada, Departament de Cirurgia, Universitat de Lleida, Lleida, Spain.

Revista Clinica Espanola

|May 17, 2021

Summary

This summary is machine-generated.

Cardiovascular risk factors like high cholesterol, smoking, and hypertension, along with comorbidities such as carotid stenosis and stroke, significantly increase the risk of severe aortic stricture in older adults.

Keywords:

Aortic stricture Cardiovascular risk factor Comorbidities Comorbilidades Epidemiology Epidemiología Estenosis aórtica Factor de riesgo cardiovascular

More Related Videos

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Published on: March 31, 2023

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Nov 5, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Published on: March 31, 2023

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

Area of Science:

Cardiovascular epidemiology
Geriatric medicine
Public health

Background:

Aortic stricture (AS) is a prevalent cardiovascular disease in individuals aged 65 and older.
Epidemiological studies suggest associations between cardiovascular risk factors (CRFs) and comorbidities with AS.

Purpose of the Study:

To evaluate the association between CRFs and comorbidities and severe symptomatic AS.
Focus on individuals aged 65 or older within a Spanish healthcare region.

Main Methods:

Case-control epidemiological study design.
Data collected from a single primary care center.
Adjusted odds ratios (OR) and multiple logistic regression models used for analysis.

Main Results:

Significant CRFs for severe symptomatic AS included hypercholesterolemia (OR, 2.67), tobacco use (OR, 2.60), hypertension (OR, 2.41), and low HDL cholesterol (OR, 2.20).
Significant comorbidities associated with severe symptomatic AS were carotid stenosis (OR, 14.5), stroke (OR, 4.14), chronic renal failure (OR, 3.78), and low hemoglobin levels (OR, 0.76).

Conclusions:

Hypercholesterolemia, tobacco use, arterial hypertension, and low HDL cholesterol are key CRFs elevating the risk of severe AS.
Comorbidities such as chronic renal failure, stroke, carotid stenosis, and low hemoglobin levels are associated with AS and may serve as potential markers.