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Updated: Nov 5, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Do internists know what limitation of therapeutic effort means?
R García-Caballero1, D Real de Asúa2, L García Olmos3
1Grupo de Trabajo de Bioética, Sociedad Española de Medicina Interna, Spain; Servicio de Medicina Interna, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain; Instituto de Ética Clínica Francisco Vallés, Universidad Europea, Madrid, Spain.
Objectives:
To ascertain whether internists know what limitation of therapeutic effort (LTE) means and whether training in palliative care affects this understanding.
Methods:
A survey was administered to Spanish internists on their knowledge of LTE and training in palliative care.
Results:
A total of 273 respondents completed the survey (mean age, 42±12 years), 80.2% of whom were associates. Some 23.8% of the respondents identified the complete definition of LTE. The most frequently selected responses were "not starting an active treatment" (85.0%) and "withdrawing an active treatment" (65.9%). Forty-three percent of the respondents lacked training in palliative care, 73.3% considered their level of understanding to be good or very good, 62.3% stated that they became anxious when addressing planning for end-of-life care with a patient, and 81.3% stated that they had experienced some conflict with their LTE decisions.
Conclusions:
Only 1 of every 4 internists knew the proper definition of LTE, with no association with the level of training in palliative care.
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