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Related Concept Videos

Echo01:06

Echo

682
The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case,...
682

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Thermal considerations for microswimmer trap-and-release using standing surface acoustic waves.

Mingyang Cui1, Minji Kim1, Patricia B Weisensee1

  • 1Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri 63130, USA. meachamjm@wustl.edu.

Lab on a Chip
|May 17, 2021
PubMed
Summary
This summary is machine-generated.

Glass-based acoustic wave devices offer superior biocompatibility for trapping motile microorganisms compared to PDMS-based systems. These devices provide strong acoustic trapping forces in a safe environment for cell research.

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Area of Science:

  • Biophysics
  • Acoustic manipulation
  • Cell biology

Background:

  • Substrate acoustic waves (SAWs) enable label- and contact-free cell trapping for biological applications.
  • Excessive heating in SAW devices can compromise cell viability and limit biocompatibility.

Purpose of the Study:

  • To investigate the thermal biocompatibility of polydimethylsiloxane (PDMS)-based SAW and glass-based SAW/bulk acoustic wave (BAW) devices.
  • To compare the acoustic trapping performance and cell viability on both device types.

Main Methods:

  • Infrared thermography was used to map temperature distributions on PDMS- and glass-based devices.
  • Motile Chlamydomonas reinhardtii algae were used to assess trapping efficiency and biocompatibility.
  • Devices were tested at varying frequencies and applied voltages.

Main Results:

  • PDMS-based SAW devices required high power, leading to rapid temperature increases and cell damage.
  • Glass-based SAW/BAW devices effectively trapped C. reinhardtii at low power with better thermal biocompatibility.
  • The glass-based system demonstrated superior performance at high power compared to PDMS.

Conclusions:

  • Glass-based SAW/BAW devices provide a biocompatible platform for acoustic trapping of microswimmers.
  • This technology offers a safe and effective solution for research involving motile cells and microorganisms.
  • Optimized acoustic trapping is crucial for maintaining cell viability in biological applications.