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Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis

Weizhe Dong1, Shorouk O Badir1, Xuange Zhang1

  • 1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

Organic Letters
|May 17, 2021
PubMed

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Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
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