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AFAP1-AS1: a rising star among oncogenic long non-coding RNAs

Fang Xiong1,2,3, Kunjie Zhu4, Su Deng1

  • 1Science and Technology on Information System Engineering Laboratory, National University of Defense Technology, Changsha, 410000, China.

Science China. Life Sciences
|May 17, 2021
PubMed

Insights

Actin filament associated protein 1-Antisense RNA 1 (AFAP1-AS1) is an oncogenic long non-coding RNA promoting tumor progression. Research highlights its potential as a molecular marker and therapeutic target in malignant tumors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression and implicated in various human diseases.
  • Actin filament associated protein 1-Antisense RNA 1 (AFAP1-AS1) is a recently identified oncogenic lncRNA.
  • AFAP1-AS1 is overexpressed in several solid tumors, influencing disease progression.

Purpose of the Study:

  • To review current research on AFAP1-AS1 in malignant tumors.
  • To explore the clinical application prospects of AFAP1-AS1 as a biomarker and therapeutic target.
  • To identify knowledge gaps and future research directions for AFAP1-AS1.

Main Methods:

  • Literature review of studies on AFAP1-AS1 function and clinical relevance.
  • Analysis of AFAP1-AS1's regulatory mechanisms, including microRNA competition and protein binding.
  • Summary of AFAP1-AS1's role in tumor proliferation, chemoresistance, apoptosis, stemness, invasion, and migration.

Main Results:

  • AFAP1-AS1 promotes tumor cell proliferation, chemoresistance, and apoptosis resistance.
  • AFAP1-AS1 maintains cancer stemness and enhances tumor cell invasion and migration.
  • AFAP1-AS1 acts through sponging microRNAs or binding to proteins to regulate downstream targets.

Conclusions:

  • AFAP1-AS1 is a significant oncogenic lncRNA with potential as a diagnostic marker and therapeutic target in cancer.
  • Further research is needed to fully elucidate AFAP1-AS1's mechanisms and clinical utility.
  • AFAP1-AS1 may serve as a model for understanding other lncRNAs in cancer.
Keywords:
AFAP1-AS1PD-1anti-cancer drugimmunotherapymetastasisproliferation

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