Recurrent episodes of palpable migratory arciform erythema associated with IVIg infusions

Area of Science:

• Dermatology
• Immunology
• Pathology

Background:

• Palpable migratory arciform erythema (PMAE) is an uncommon T cell pseudolymphoma.
• PMAE presents as erythematous, annular-to-arciform papules and plaques.
• While typically self-limited, PMAE often recurs, and triggers are not well-established.

Purpose of the Study:

• To report a case of recurrent PMAE.
• To investigate the potential association between IVIg infusions and PMAE development.
• To contribute to the understanding of PMAE triggers.

Main Methods:

• Clinical case presentation of a 60-year-old male patient.
• Detailed observation of skin eruption following IVIg infusion.
• Histopathologic analysis for diagnostic confirmation.

Main Results:

• The patient developed recurrent PMAE after IVIg infusions.
• Each episode of PMAE was self-limited, resolving within weeks.
• Subsequent IVIg infusions consistently triggered the recurrence of PMAE.

Conclusions:

• IVIg infusion is identified as a potential trigger for recurrent PMAE.
• This is the first reported case linking IVIg infusions to recurrent PMAE.
• Further investigation into IVIg as a PMAE trigger is warranted.