Related Experiment Videos
Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13
S Ingvarsson1, C Asker, J Szpirer
1Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Somatic Cell and Molecular Genetics
|July 1, 1988
Abstract:
Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat x mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.