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Updated: Nov 5, 2025

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Pachychoroid diseases

Róbert Gergely1, Mónika Ecsedy1, Illés Kovács1

  • 11 Semmelweis Egyetem, Általános Orvostudományi Kar, Szemészeti Klinika, Budapest, Üllői u. 26., 1085.

Orvosi Hetilap
|May 17, 2021
PubMed
Summary

This study reviews pachychoroid diseases, including central serous chorioretinopathy (CSCR) and others, highlighting their common choroidal abnormalities. It summarizes effective treatments like eplerenone and laser therapy for specific subgroups.

Keywords:
PDTanti-VEGFeplerenonemicropulse lasermikropulzuslézerpachychorioidealis kórképekpachychoroid disease

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroidal Abnormalities

Background:

  • Pachychoroid diseases encompass a spectrum of conditions characterized by choroidal abnormalities.
  • These conditions, including central serous chorioretinopathy (CSCR), often involve subretinal fluid accumulation.
  • A unified treatment protocol is lacking, with varying efficacy across disease subgroups.

Purpose of the Study:

  • To consolidate current knowledge on pachychoroid diseases.
  • To present clinical experiences and literature review findings.
  • To create a treatment algorithm for different pachychoroid disease subgroups.

Main Methods:

  • Case reports compilation.
  • Comprehensive literature review.
  • Analysis of clinical experiences.

Main Results:

  • Pachychoroid diseases share abnormal choroidal structure and potential subretinal fluid.
  • Specific treatments like eplerenone, micropulse laser, verteporfin photodynamic therapy, and anti-VEGF injections show differential efficacy.
  • A treatment flowchart was developed based on subgroup analysis.

Conclusions:

  • Pachychoroid diseases require tailored treatment strategies.
  • Understanding subgroup-specific responses to therapies is crucial for effective management.
  • Further research may refine treatment protocols for these conditions.