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Propagation of Action Potentials

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...

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Related Experiment Video

Updated: Nov 5, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Cortical propagation tracks functional recovery after stroke.

Gloria Cecchini^1,2,3, Alessandro Scaglione^2,4, Anna Letizia Allegra Mascaro^4,5

¹Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain.

Plos Computational Biology

|May 17, 2021

Summary

This summary is machine-generated.

New biomarkers track stroke recovery by analyzing brain activity patterns. These indicators reveal how rehabilitation therapies improve cortical function, paving the way for targeted stroke treatments.

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Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

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Last Updated: Nov 5, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

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Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

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Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Area of Science:

Neuroscience
Biomarkers
Rehabilitation Science

Background:

Stroke is a leading cause of long-term disability worldwide.
Effective rehabilitation requires biomarkers to monitor functional deficits and recovery.
Current methods for tracking stroke recovery lack precision in assessing neural activity.

Purpose of the Study:

To identify novel biomarkers for tracking functional damage and recovery after stroke.
To analyze spatiotemporal patterns of cortical activity using wide-field calcium imaging in mice.
To compare the efficacy of different post-stroke rehabilitation paradigms.

Main Methods:

Spatiotemporal analysis of cortical activity via wide-field calcium imaging in mice.
Comparison of spontaneous recovery with motor training, pharmacological inactivation, and combined interventions.
Identification and validation of novel propagation indicators: duration, smoothness, and angle.

Main Results:

Cortical activity propagation is slowed and irregular in the subacute phase post-stroke.
Combined motor training and pharmacological intervention led to generalized recovery.
This combined treatment group exhibited enhanced cortical activity patterns, faster and smoother than pre-stroke.

Conclusions:

Novel spatiotemporal propagation indicators show promise as biomarkers for stroke recovery.
These biomarkers can reveal neural correlates of motor deficits and rehabilitation progress.
Findings may guide the development of more targeted and effective post-stroke therapies.