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Related Experiment Videos

Diabetic dimorphism according to acetylator status.

A W Burrows, T D Hockaday, J I Mann

    British Medical Journal
    |January 28, 1978
    PubMed
    Summary

    Diabetics, particularly those with maturity onset diabetes, are often fast acetylators of sulphadimidine. This acetylator status is linked to higher insulin levels and secretion, though its role in diabetic complications remains unclear.

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    Area of Science:

    • Pharmacogenetics
    • Endocrinology
    • Metabolic Diseases

    Background:

    • Acetylator status, a genetically determined metabolic trait, influences drug metabolism.
    • Diabetes mellitus is a complex metabolic disorder with significant public health implications.
    • Understanding factors influencing diabetes progression and complications is crucial for effective management.

    Purpose of the Study:

    • To investigate the prevalence of fast and slow acetylators of sulphadimidine in patients with diabetes mellitus.
    • To explore the relationship between acetylator status and clinical characteristics in maturity onset diabetes.
    • To assess the impact of acetylator status on insulin secretion and response to dietary treatment in diabetics.

    Main Methods:

    • Measurement of sulphadimidine acetylation rate in two groups of diabetic patients and normal controls.
    • Comparison of clinical parameters (age at diagnosis, fasting insulin, glucose concentration) between fast and slow acetylators.
    • Assessment of first-phase insulin secretion in response to intravenous glucose before and after dietary intervention.

    Main Results:

    • A higher proportion of fast acetylators was observed in patients with maturity onset diabetes compared to normal controls.
    • Fast acetylators with maturity onset diabetes were older at diagnosis and exhibited higher fasting insulin levels.
    • Fast acetylators demonstrated enhanced first-phase insulin secretion, particularly after dietary treatment.

    Conclusions:

    • Diabetic patients, especially those with maturity onset diabetes, are unexpectedly frequently fast acetylators.
    • The observed association between fast acetylation and improved insulin secretion suggests a potential metabolic link.
    • Further research is needed to determine if acetylator status influences the risk of diabetic neuropathy or other tissue damage.

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