Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

14.2K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
14.2K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

16.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
16.3K
Regulation of Metabolism01:19

Regulation of Metabolism

10.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.5K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

9.6K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
9.6K
Mitochondria01:37

Mitochondria

17.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
17.0K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

4.0K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PPAR<sub>α</sub> Dependent Regulation of Gut Microbiota: Implication for Host Metabolic Homeostasis.

Molecular nutrition & food research·2026
Same author

Protein-rich food matrices from alternative and conventional sources differentially shape gut microbiota, metabolic function, and muscle protein synthesis.

NPJ science of food·2026
Same author

Insights into the mitochondrial genomes of Taenia tapeworms.

Molecular biology reports·2026
Same author

Purple sweet potato (Ipomoea batatas L. Lam) leaves extract prevents weight gain and lipotoxicity in mice fed a high-fat diet by increasing metabolic flexibility and oxidative metabolism in skeletal muscle and brown adipose tissue.

Nutrition & metabolism·2026
Same author

Energy restriction and iron supplementation improve iron status in women with obesity regardless of red meat consumption: a randomized controlled trial.

Scientific reports·2026
Same author

In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines.

Prostate cancer·2026

Related Experiment Video

Updated: Nov 5, 2025

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.2K

Dietary bioactive compounds as modulators of mitochondrial function.

Sarai Vásquez-Reyes1, Laura A Velázquez-Villegas1, Ariana Vargas-Castillo1

  • 1Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México CDMX, Mexico.

The Journal of Nutritional Biochemistry
|May 17, 2021
PubMed
Summary

Dietary bioactive compounds can improve mitochondrial function, offering a novel strategy to combat metabolic diseases like diabetes and obesity. Further human studies are needed to confirm their therapeutic potential.

Keywords:
AMPKDietary bioactive compoundsMitochondrial activityOxygen consumptionSIRT1Thermogenesis

More Related Videos

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
08:15

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis

Published on: February 3, 2022

3.4K
Mitochondrial Respiration Quantification in Yeast Whole Cells
07:15

Mitochondrial Respiration Quantification in Yeast Whole Cells

Published on: November 8, 2024

844

Related Experiment Videos

Last Updated: Nov 5, 2025

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.2K
Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
08:15

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis

Published on: February 3, 2022

3.4K
Mitochondrial Respiration Quantification in Yeast Whole Cells
07:15

Mitochondrial Respiration Quantification in Yeast Whole Cells

Published on: November 8, 2024

844

Area of Science:

  • Nutritional Science
  • Mitochondrial Biology
  • Metabolic Health

Background:

  • Metabolic diseases (diabetes, obesity, metabolic syndrome) are a global health concern.
  • Nutritional strategies targeting mitochondrial activity offer a new approach to managing energy metabolism.
  • Dietary bioactive compounds (food bioactives) show promise in counteracting metabolic dysfunction.

Purpose of the Study:

  • To review and summarize evidence on how dietary bioactive compounds affect mitochondrial activity.
  • To explore the link between these mitochondrial effects and pathological conditions.
  • To assess the potential of food bioactives as adjuvant therapies for metabolic disorders.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of in vivo and in vitro studies.
  • Focus on evidence linking bioactive compounds to mitochondrial function and metabolic health.

Main Results:

  • Dietary bioactive compounds demonstrably modulate mitochondrial activity.
  • Mitochondrial function modulation is a key mechanism underlying the health benefits of food bioactives.
  • Evidence suggests these compounds can counteract metabolic alterations.

Conclusions:

  • Dietary bioactive compounds show potential for improving mitochondrial function and treating metabolic diseases.
  • More human clinical trials are necessary to validate the effectiveness of these compounds.
  • Mitochondrial modulation by food bioactives represents a promising area for therapeutic intervention.