A new index for evaluating the fit of dose distribution to target volume: Dose distribution fix index

To develop a new dose evaluation index, fit index (FI), to help evaluate the fit between isodose surfaces at different percentages of the prescription dose and the target volume. Two types of FI, differential and cumulative, were defined. The differential fit index (dFI) was defined as the ratio of the integral dose of volume occupied by an isodose surface to the integral dose of the planning target volume. The cumulative fit index (cFI) was defined as the integral of dFI from the minimum dose of clinical significance to the 100% prescription dose. Performance of the cFI was evaluated with virtual dose distributions. In addition, non-coplanar and coplanar VMAT plans of 20 brain metastasis cases were evaluated using the FI, and the results were compared with results from the dose gradient index (GI) and conformity index (CI). Correlations between cFI and GI, and between cFI and CI were studied and Pearson's correlation coefficients were calculated. dFI and cFI provided comprehensive and objective results in evaluating the dose fit between isodose surfaces at different percentages of the prescription dose and the target volume. Analysis showed a positive correlation between cFI and GI with a Pearson correlation coefficient of 0.928 (p < 0.01) and a negative correlation between cFI and CI with a Pearson correlation coefficient of -0.831 (p < 0.01). dFI and cFI were shown to be effective and convenient tools for evaluating the dose fit of a radiotherapy plan.