Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

383
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
383
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

58
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
58
Bone Disorders01:29

Bone Disorders

4.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.6K
Nature and Nurture01:10

Nature and Nurture

21.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
21.3K
Mitochondria01:37

Mitochondria

17.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
17.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of Comorbid Postpartum Depression and Anxiety in Birthing Parents Seeking Treatment for Postpartum Depression: Prévalence de la présence comorbide de la dépression et de l'anxiété post-partum chez les parents ayant accouché qui ont consulté en raison de la dépression post-partum.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2026
Same author

Decreased variability of small-world propensity during non-response tasks in schizophrenia.

Neuroimage. Reports·2026
Same author

Patterns of heart rate variability (HRV) responses to acute skin-breaking procedures in neonates: a systematic review and meta-analysis.

Pain·2026
Same author

Feasibility, reproducibility, and cold-induced energy expenditure using whole-room calorimetry in adults and children.

Journal of the Endocrine Society·2026
Same author

Dyslipidemia in children: diagnosis, evaluation, and management.

Paediatrics & child health·2026
Same author

Prevalence of Metabolically Healthy Obesity in Canadian Children and Adolescents at Entry to Pediatric Weight Management Clinic and One Year Later: A Secondary Analysis of CANadian Pediatric Weight Management Registry Data.

Childhood obesity (Print)·2026

Related Experiment Video

Updated: Nov 5, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.7K

Extremely Low Birth Weight and Accelerated Biological Aging.

Ryan J Van Lieshout1, Patrick O McGowan2, Wilfred C de Vega2

  • 1Departments of Psychiatry and Behavioural Neurosciences.

Pediatrics
|May 18, 2021
PubMed
Summary

Men born extremely low birth weight (ELBW) may experience accelerated aging compared to normal birth weight (NBW) peers. This study used epigenetic clocks to assess biological aging in ELBW survivors. Further research is needed to promote healthy aging in preterm infants.

More Related Videos

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.5K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.3K

Related Experiment Videos

Last Updated: Nov 5, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.7K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.5K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.3K

Area of Science:

  • Epigenetics
  • Aging Research
  • Perinatal Medicine

Background:

  • Extremely low birth weight (ELBW) survivors face physiological stress, potentially leading to accelerated aging.
  • Longitudinal studies on ELBW survivors are crucial for understanding long-term health outcomes.
  • Biological aging markers in ELBW individuals require further investigation.

Purpose of the Study:

  • To compare biological aging between extremely low birth weight (ELBW) survivors and normal birth weight (NBW) controls.
  • To investigate the role of epigenetic clocks in assessing aging in ELBW individuals.
  • To identify sex-specific differences in aging patterns among ELBW survivors.

Main Methods:

  • Utilized buccal cells from 45 ELBW survivors and 49 NBW controls aged 30-35 years.
  • Calculated epigenetic age using DNA methylation data from a 353-cytosine-phosphate-guanine site epigenetic clock.
  • Employed the Illumina Infinium Human Methylation EPIC 850k BeadChip array for methylation analysis.

Main Results:

  • A significant sex by birth weight group interaction was found in epigenetic age (P = .03).
  • ELBW men exhibited significantly older epigenetic age (4.6 years, P = .01) compared to NBW men.
  • No significant difference in epigenetic age was observed between ELBW women and NBW women.

Conclusions:

  • Prenatal exposures may significantly influence the aging process.
  • Men born preterm may experience accelerated biological aging.
  • Monitoring and promoting healthy aging in preterm survivors, especially men, is essential.