Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibrous Dysplasia With 99m Tc-FAPI Uptake in a Patient Under Long-term Antiresorptive Therapy.

Clinical nuclear medicine·2026
Same author

AI-augmented thyroid scintigraphy for robust classification of disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

99mTc‑FAPI‑46 Scintigraphy for Staging of Non-Small Cell Lung Carcinoma.

Clinical nuclear medicine·2026
Same author

Imaging Atlas of Osseous Pathology in the Ankle and Foot.

The archives of bone and joint surgery·2026
Same author

Sudden Diffuse Hepatic Metastases After First 177Lu-PSMA Cycle in Bone Predominant mCRPC Patient.

Clinical nuclear medicine·2026
Same author

Maximizing diagnostic yield: A systematic review and deep dive into PSMA PET scan protocol variations for prostate cancer.

Seminars in nuclear medicine·2026

Related Experiment Video

Updated: Nov 5, 2025

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

20.4K

Repeat injection following sentinel node nonvisualization on lymphoscintigraphy images can decrease axillary

Atena Aghaee1, Ehasn Soltani2, Sara Jangjoo3

  • 1Nuclear Medicine Research Center.

Nuclear Medicine Communications
|May 18, 2021
PubMed
Summary
This summary is machine-generated.

Radiotracer reinjection significantly improves sentinel node detection in early-stage breast cancer patients when initial lymphoscintigraphy fails. This method helps avoid unnecessary axillary lymph node dissections.

More Related Videos

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

3.4K
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.5K

Related Experiment Videos

Last Updated: Nov 5, 2025

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

20.4K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

3.4K
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.5K

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Surgical Oncology

Background:

  • Sentinel node biopsy is the standard for early-stage breast cancer.
  • Accurate sentinel node identification is crucial for staging and treatment planning.
  • Nonvisualization of sentinel nodes on lymphoscintigraphy poses a challenge.

Purpose of the Study:

  • To evaluate the impact of radiotracer reinjection on sentinel node visualization.
  • To assess the effectiveness of reinjection in improving detection rates.
  • To determine if reinjection can reduce unnecessary axillary dissections.

Main Methods:

  • A study involving 1850 early-stage breast cancer patients undergoing sentinel node mapping.
  • Tc-99m Phytate was used as the radiotracer, injected intradermally.
  • Patients with initial nonvisualization underwent a second injection and immediate lymphoscintigraphy.

Main Results:

  • Reinjection successfully visualized sentinel nodes in 155 out of 200 patients (77.5%) in the reinjection group.
  • The detection rate increased significantly with reinjection compared to no reinjection.
  • Sentinel node nonvisualization after reinjection was associated with a higher rate of axillary involvement.

Conclusions:

  • Reinjection of radiotracer is an effective strategy to increase sentinel node detection rates.
  • This technique can help avoid unnecessary axillary lymph node dissections in breast cancer patients.
  • Optimizing lymphoscintigraphy protocols enhances the accuracy of breast cancer staging.