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Related Experiment Video

Updated: Nov 5, 2025

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SARS-CoV-2 cell entry and targeted antiviral development.

Zinuo Chen1, Ruikun Du1,2,3, Jazmin M Galvan Achi4

  • 1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Acta Pharmaceutica Sinica. B
|May 18, 2021
PubMed
Summary

This review summarizes SARS-CoV-2 cell entry mechanisms and antiviral strategies. It discusses developing next-generation inhibitors for future pandemic preparedness against COVID-19.

Keywords:
Antiviral developmentCell entryPost-pandemicSARS-CoV-2Spike protein

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Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic.
  • Understanding viral entry is crucial for developing effective therapies.
  • The initial cell entry step is a key target for antiviral interventions.

Purpose of the Study:

  • To review current knowledge on SARS-CoV-2 cell entry.
  • To summarize the development of antiviral strategies targeting viral entry.
  • To explore future directions for next-generation SARS-CoV-2 entry inhibitors.

Main Methods:

  • Literature review of SARS-CoV-2 cell entry mechanisms.
  • Analysis of current antiviral strategies targeting SARS-CoV-2.
  • Speculative outlook on future inhibitor development.

Main Results:

  • Detailed summary of SARS-CoV-2 cell entry pathways.
  • Overview of established and emerging antiviral therapies.
  • Identification of potential targets for future inhibitor design.

Conclusions:

  • Targeting SARS-CoV-2 cell entry is a promising therapeutic approach.
  • Continued research is needed to develop novel entry inhibitors.
  • Future strategies should focus on broad-spectrum inhibitors for pandemic preparedness.