Related Experiment Video
Updated: Nov 5, 2025
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
Cu2-Se/Bi2Se3@PEG Z-scheme heterostructure: a multimode bioimaging guided theranostic agent with enhanced
Ying Wang1, Wenjia Wang2, Dongmiao Sang2
1Key Laboratory of Photochemical Biomaterials and Energy Storage Materials and College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, China. linhuiming@hrbnu.edu.cn qufengyu@hrbnu.edu.cn and Key Laboratory of Cluster Science, Ministry of Education of China, Beijing, Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Abstract:
Photodynamic therapy (PDT) can be defined as a kind of intracellular photocatalysis. Inspired by the design of photocatalysts, the construction of the heterojunction also is expected to improve the production of reactive oxygen species (ROS) for PDT. Herein, the Cu2-xSe/Bi2Se3@PEG (CB3@PEG) nano-heterostructure has been prepared by a cation-exchange process, where the interaction between the host and exchange agent is vital. CB3@PEG exhibits the near-infrared (NIR)-triggered hydroxyl radical and singlet oxygen (˙OH and 1O2) generation, which is more than 6 times in contrast with that of pure Cu2-xSe@PEG, attributed to the Z-scheme charge transfer mechanism with the high redox ability and great charge separation. Moreover, with the narrower band gap of Bi2Se3, CB3@PEG exhibits enhanced NIR harvest as well as high photothermal conversion efficiency (60.4%). Due to the Fenton reaction caused by the Cu ion, CB3@PEG is endowed with the chemodynamic therapy (CDT) and signal-enhanced T1-weight magnetic resonance imaging (MRI) capacity. In addition, the great photothermal ability and X-ray absorption coefficient provide outstanding contrast in photothermal imaging (PTI) and computerized tomography (CT) imaging. Finally, the multi-imaging combined with the synergistic treatment (PTT/CDT/PDT) makes CB3@PEG achieve enhanced efficiency in anticancer therapy.
