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Updated: Nov 5, 2025

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Fenoldopam and renal hemodynamics in shiga toxin-related hemolytic uremic syndrome
Gianluigi Ardissino1, Antenore Giussani2, Valentina Capone3
1Center for HUS Prevention Control and Management at the Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 9, 20122, Milano, Italy. ardissino@centroseu.org.
Background:
Fenoldopam, a vasodilating agent, may represent a potential therapeutic opportunity to increase renal perfusion in those conditions where renal hemodynamics are severely impaired by vascular sub-occlusion, as, indeed, is the case in thrombotic microangiopathies.
Methods:
The renal resistance index (RRI) was measured, on and off fenoldopam, in 27 children with STEC-HUS.
Results:
A 12% decrease in RRI was observed on fenoldopam compared to off treatment without changes in the systemic hemodynamics and with no side effects.
Conclusions:
If confirmed in larger series, fenoldopam may become an important addition to supportive care to reduce ischemic damage in STEC-HUS and improve long-term outcomes.
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