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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Related Experiment Video

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Pediatric problematic severe asthma: Recent advances in management.

Elizabeth Scotney1,2, Saskia Burchett2, Thomas Goddard2,3

  • 1National Heart & Lung Institute, Imperial College London, London, UK.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
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Severe asthma in children is hard to manage. This review highlights new biomarkers for severe asthma and stresses the need for more research in children under 12.

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Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Biomarker Discovery

Background:

  • Severe asthma in children presents significant management challenges and high healthcare utilization.
  • Difficult-to-treat asthma (DA) and severe therapy-resistant asthma (STRA) phenotypes are recognized, with emerging molecular distinctions.
  • The role of airway neutrophils in childhood severe asthma remains unclear, impacting treatment strategies.

Purpose of the Study:

  • To review recent advances in objective biomarkers for stratifying and managing childhood severe asthma.
  • To identify critical gaps in pediatric evidence for severe asthma management.
  • To emphasize the urgent need for efficacy studies in younger children (under 12 years).

Main Methods:

  • Literature review focusing on recent advancements in severe asthma biomarkers.
  • Analysis of current evidence on novel treatment strategies in pediatric severe asthma.
  • Examination of pediatric data limitations for novel therapies.

Main Results:

  • Objective biomarkers show promise for improving severe asthma stratification.
  • Significant gaps exist in pediatric data, particularly for novel treatments in children under 12.
  • Current evidence on airway inflammation markers in STRA shows poor correlation between peripheral and airway sites.

Conclusions:

  • Objective biomarkers are crucial for advancing the management of childhood severe asthma.
  • There is a critical need for robust pediatric clinical trials, especially for children under 12.
  • Further research is required to elucidate the role of neutrophils and optimize novel therapies for severe pediatric asthma.