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Updated: Nov 5, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Biomarkers in Migraine.
Brian M Yan1, E M Gibson Depoy2, Ayesha Ahmad2
1Sidney Kimmel Medical College, Thomas Jefferson University, USA.
Neurology India
|May 18, 2021
Summary
Migraine biomarkers are being researched for diagnosis and treatment. While many diagnostic markers exist, calcitonin gene-related peptide (CGRP) and PACAP-38 show promise for targeted migraine therapies.
Area of Science:
- Neurology
- Biochemistry
- Genetics
Background:
- Migraine disability significantly impacts global economies.
- Ongoing research seeks diagnostic and therapeutic biomarkers for migraine.
- Biomarkers are crucial for advancing precision medicine in neurology.
Purpose of the Study:
- To review current diagnostic and therapeutic migraine biomarkers.
- To evaluate the role of these biomarkers in precision medicine.
- To identify key biomarkers with clinical relevance.
Main Methods:
- Comprehensive literature search of PubMed, Google Scholar, and clinicaltrials.gov.
- Keywords included "migraine," "headache," "biomarkers," "serum," "cerebral spinal fluid," "inflammatory," and "neuroimaging."
- Analysis of 88 relevant research papers.
Main Results:
- Numerous biomarkers support migraine diagnosis.
- Calcitonin gene-related peptide (CGRP) and PACAP-38 are key therapeutic biomarkers.
- Genetic markers and associated biochemical alterations show potential.
Conclusions:
- Several proposed biomarkers exist for migraine.
- Further research is necessary to validate biomarkers for clinical use.
- Biomarker research is essential for advancing migraine treatment.
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