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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Medication Overuse Headache.

Girish Baburao Kulkarni1, Thomas Mathew2, Pooja Mailankody1

  • 1Department of Neurology, NIMHANS, Bengaluru, Karnataka, India.

Neurology India
|May 18, 2021
PubMed
Summary
This summary is machine-generated.

Medication overuse headache (MOH) is a disabling disorder affecting 1% of the global population. Effective management involves patient education, medication withdrawal, and prophylactic treatments for primary headaches.

Keywords:
Analgesic overusechronic headachedrug withdrawaleducationmedication overuseopioidssecondary headachetriptans

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Medication overuse headache (MOH) is a disabling headache disorder affecting approximately 1% of the global population.
  • It is characterized by frequent headaches (≥15 days/month) due to regular overuse of acute symptomatic medications for over three months.
  • MOH develops in patients with pre-existing primary headache disorders.

Purpose of the Study:

  • To review the current understanding of Medication Overuse Headache (MOH).
  • To present updated information on the pathophysiology and treatment of MOH.

Main Methods:

  • A literature search was conducted using PubMed/MEDLINE and Cochrane databases.
  • Relevant full-text articles were reviewed to compile the information for this review.

Main Results:

  • The pathophysiology of MOH is complex and involves genetic predisposition, altered pain pathways, and changes in brain regions and neurotransmitters related to pain perception.
  • Differentiating MOH from other chronic daily headaches requires careful patient history, examination, and medication intake assessment.
  • Treatment strategies include patient education, withdrawal of the overused medication, and initiation of preventive therapy for the underlying primary headache disorder.

Conclusions:

  • Medication Overuse Headache (MOH) is a secondary headache disorder that must be considered in patients with chronic headaches.
  • Multiple pathophysiological mechanisms contribute to MOH development.
  • Management encompasses patient education, detoxification from the offending medication, and appropriate prophylactic therapy.