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Published on: June 2, 2014
Migraine and Vascular Risk: An Update
Anu Gupta1, M V Padma Srivastava1
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Migraine, especially with aura, is linked to increased vascular risks like stroke, particularly in young women. Managing cardiovascular risk factors is crucial for migraine patients.
Area of Science:
- Neurology
- Cardiology
- Epidemiology
Background:
- Migraine is a prevalent neurological disorder causing significant disability.
- Growing evidence links migraine to cardiovascular diseases and stroke.
Purpose of the Study:
- To update knowledge on the association between migraine and common vascular diseases.
- To discuss clinical implications of this association.
Main Methods:
- Searched PubMed using MeSH terms for stroke, coronary artery disease, and migraine subtypes.
- Reviewed relevant English-language articles from the past 10 years, including older key studies.
- Examined reference lists and included reviews on 'Migraine and Vascular Risk'.
Main Results:
- A strong, consistent association exists between migraine with aura and ischemic stroke, especially in young women using oral contraceptives and smoking.
- The migraine-vascular link persists even after adjusting for traditional risk factors, suggesting a specific pathophysiology.
- Evidence suggests an adverse vascular risk profile in migraineurs, with variable associations for hemorrhagic stroke.
Conclusions:
- While the absolute vascular risk increase from migraine is small, managing traditional cardiovascular risk factors is essential.
- Lifestyle modifications, smoking cessation, and careful use of certain medications are recommended.
- A thorough risk-benefit analysis is advised for medications like ergot alkaloids and oral contraceptives in migraine patients.
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