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HIF1α or HIF2α: Enhancing CD8+ T-cell Fitness for Antitumor Immunity

Jin Chen1

  • 1Vanderbilt University Medical Center, Nashville, Tennessee. jin.chen@vumc.org.

Cancer Immunology Research
|May 18, 2021
PubMed

Adoptive T-cell therapy requires the transferred lymphocytes to adapt to the hypoxic tumor microenvironment. In this issue, Veliça and colleagues found that modified HIF2α expression in CD8+ T cells increases antitumor efficacy.See article by Veliça et al., p. 401.

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