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Updated: Nov 5, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Conditional Cancer Immunotherapy as a Safer Way to Step on the Gas
Bridget P Keenan1, Lawrence Fong2
1Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California.
Abstract:
In this issue, Kamata-Sakurai and colleagues describe an agonist antibody to CD137 (4-1BB) that takes on an active conformation in environments with high ATP concentrations, characteristic of tumors. This represents a novel advancement in developing immunotherapies that can be administered systemically, but act locally to induce antitumor immune responses without the usual attendant toxicities.See related article by Kamata-Sakurai et al., p. 158.
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