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Lifetime Corneal Edema Load Model.

Russell Thomson1, Rabia Mobeen2, Arthur Ho2,3

  • 1Western Sydney University, Penrith, NSW, Australia.

Translational Vision Science & Technology
|May 18, 2021
PubMed
Summary
This summary is machine-generated.

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High oxygen transmissibility (Dk/t) silicone hydrogel daily disposable contact lenses minimize corneal swelling, even with noncompliance or extended wear. This is crucial for maintaining long-term ocular health over decades.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Corneal Physiology

Background:

  • Daily disposable (DD) contact lenses offer convenience, but long-term wear, especially with noncompliance or high oxygen demands, can lead to corneal edema.
  • Silicone hydrogel materials have improved oxygen transmissibility (Dk/t) compared to traditional hydrogels.
  • Understanding the impact of Dk/t and wear patterns on corneal health is vital for patient management.

Purpose of the Study:

  • To evaluate the long-term benefits of silicone hydrogel DD contact lenses, focusing on patients with noncompliant wear habits, including sleeping or napping.
  • To assess the impact of varying oxygen transmissibilities (Dk/t) on corneal edema over extended wear periods.
  • To compare corneal swelling in high and average corneal swellers wearing different contact lens modalities.

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Main Methods:

  • Utilized published data on corneal swelling from lens wear and non-lens wear to develop a nonlinear least squares model.
  • Quantified edema load based on a range of Dk/t values and wear compliance, including sleep and napping.
  • Employed a mixed-effects linear regression model to compare edema load between high and average corneal swellers.

Main Results:

  • High Dk/t silicone hydrogel lenses result in corneal edema levels comparable to no lens wear.
  • Compared to high Dk/t lenses, hydrogels with a Dk/t of 27 result in 1.5 times more edema, increasing to two times more with noncompliance per decade.
  • Over four decades, high corneal swellers may experience edema loads 10 to 17 times greater than average swellers, depending on Dk/t and compliance.

Conclusions:

  • Prescribing high Dk/t silicone hydrogel DD lenses can help preserve long-term ocular health for patients wearing lenses full-time for decades.
  • Emphasizes the critical role of Dk/t in contact lens wear, particularly for modalities involving naps, sleep, or high patient oxygen requirements.