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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Advances of circular RNAs in thyroid cancer: An overview

Xiao Li1, Wei Jiang1, Yi Zhong2

  • 1Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 18, 2021
PubMed

Insights

Circular RNAs (circRNAs) are novel RNA molecules with diverse functions. This review highlights their emerging roles and mechanisms in thyroid cancer, offering new therapeutic perspectives.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules derived from precursor mRNAs.
  • They function as microRNA sponges, protein scaffolds, and regulators of transcription and splicing.
  • Emerging evidence suggests circRNAs are involved in polypeptide production.

Purpose of the Study:

  • To review the latest advances in circRNA research.
  • To summarize the regulatory mechanisms of circRNAs.
  • To focus on the role and mechanisms of circRNAs in thyroid cancer.

Main Methods:

  • Literature review of circRNA research.
  • Analysis of circRNA functions in gene regulation.
  • Synthesis of current knowledge on circRNAs in thyroid carcinoma.

Main Results:

  • CircRNAs exhibit diverse biological functions, including gene regulation and protein interactions.
  • Their roles in thyroid cancer are increasingly recognized.
  • Understanding circRNA mechanisms provides insights into thyroid cancer pathogenesis.

Conclusions:

  • CircRNAs represent a significant area of molecular biology research.
  • Their dysregulation is implicated in various diseases, including cancer.
  • This review provides a theoretical basis for exploring circRNAs as therapeutic targets in thyroid cancer.
Keywords:
Circular RNADiagnosisTargeted therapyThyroid carcinoma

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