Related Experiment Video

Updated: Nov 5, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients

Thomas Ebert1, Ognian Neytchev2, Anna Witasp1

  • 1Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Antioxidants & Redox Signaling
|May 19, 2021
PubMed

Insights

Chronic kidney disease (CKD) involves inflammation and oxidative stress, similar to aging. Systemic interventions targeting these processes may improve health span and reduce CKD burden.

Area of Science:

  • Nephrology
  • Gerontology
  • Oxidative Stress Research

Background:

  • Chronic kidney disease (CKD) is a lifestyle disease linked to aging, characterized by inflammation, oxidative stress, vascular aging, and cellular senescence.
  • A systemic approach to mitigate these adverse components offers potential to attenuate CKD effects and associated morbidities.
  • Interventions like pharmacological, nutritional, and lifestyle changes are explored to manage CKD.

Purpose of the Study:

  • To review current concepts of inflammation and oxidative damage as key CKD pathomechanisms.
  • To discuss the beneficial and adverse effects of various systemic interventions in CKD patients.
  • To explore novel therapeutic avenues for reducing CKD burden and improving patient outcomes.

Main Methods:

  • Review of current literature on inflammation and oxidative stress in CKD.
  • Analysis of systemic interventions including senotherapeutics, NRF2-KEAP1 pathway modulators, klotho axis, SGLT2 inhibitors, and live bio-therapeutics.
  • Discussion of potential benefits and risks associated with these interventions.

Main Results:

  • Inflammation and oxidative stress are central pathomechanisms in CKD.
  • Several interventions show promise in mitigating CKD progression and related complications.
  • Specific pathways and agents like senotherapeutics, NRF2-KEAP1, klotho axis, SGLT2 inhibitors, and live bio-therapeutics are highlighted for their potential.

Conclusions:

  • Systemic interventions targeting inflammation, oxidative stress, and cellular senescence can potentially attenuate CKD progression and associated morbidities.
  • Senotherapeutics, NRF2-KEAP1 pathway, klotho axis, SGLT2 inhibitors, and live bio-therapeutics represent promising strategies to improve quality of life, morbidity, and mortality in CKD patients.
  • A comprehensive approach is needed to manage the complex burden of CKD and enhance health span in this patient group.

Keywords:
agingallostatic loadchronic kidney diseaseend-stage kidney diseaseinflammationoxidative stresspremature agingsenescenceuremic toxins

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.3K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

411

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
310
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
168
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
238
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
110
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
465
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
100