Related Experiment Video
Updated: Nov 5, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
[Corticosteroid Therapy in Patients with Autoimmune Diseases of the Central Nervous System]
1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
Abstract:
Corticosteroids play an important role in the treatment of inflammatory disorders including neuroinflammatory diseases. Corticosteroids with glucocorticoid receptors directly regulate transcription of many genes associated with inflammation and interfere with pro-inflammatory transcription factors. Glucocorticoids produce non-genomic effects by intercalation into the plasma membrane. These effects differ depending on the immunophenotype of immune cells. The corticosteroid dosage that is effective against inflammatory disorders depends on the pathological background of autoimmune diseases; however, owing to limited clinical evidence, the dosage has been empirically determined in routine medical practice. The corticosteroid dosage should be <7.5mg prednisolone equivalent/day to reduce the risk of adverse effects associated with these drugs.
More Related Videos
09:38Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
08:47Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...