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[Sjögren's Syndrome].

Tatsusada Okuno1, Hisashi Murata

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Brain and Nerve = Shinkei Kenkyu No Shinpo
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Summary
This summary is machine-generated.

Sjögren's syndrome, an autoimmune condition, can cause neurological issues in up to 60% of patients. Neurological symptoms may appear before diagnosis, making Sjögren's a key consideration for unexplained neurological conditions.

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Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Sjögren's syndrome is an autoimmune disorder primarily affecting salivary and lacrimal glands.
  • Extraglandular manifestations are common, including a range of neurological complications.
  • Neurological symptoms can precede the diagnosis of Sjögren's syndrome.

Purpose of the Study:

  • To highlight the significant association between Sjögren's syndrome and neurological complications.
  • To emphasize the importance of considering Sjögren's syndrome in patients presenting with neurological symptoms.

Main Methods:

  • Review of existing literature on Sjögren's syndrome and its neurological manifestations.
  • Analysis of reported frequencies and types of neurological complications.
  • Evaluation of the temporal relationship between neurological symptoms and Sjögren's diagnosis.

Main Results:

  • Neurological complications occur in 1.8% to 60% of Sjögren's syndrome patients.
  • Manifestations include central, peripheral, and muscular neurological disorders.
  • In 25% of cases, neurological symptoms are the initial presentation.

Conclusions:

  • Neurological complications are a frequent and varied extraglandular manifestation of Sjögren's syndrome.
  • Sjögren's syndrome should be considered in the differential diagnosis of unexplained neurological symptoms.
  • Early consideration of Sjögren's syndrome may improve patient outcomes.