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Related Experiment Videos

How much theophylline is enough?

R D Fairshter1

  • 1Department of Medicine, University of California, Irvine.

The American Journal of Medicine
|July 29, 1988
PubMed
Summary

Theophylline offers bronchodilation and other benefits for asthma. Optimal therapeutic effects, including bronchodilation, are achieved at specific serum theophylline concentrations, with nighttime dosing potentially maximizing benefits.

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Area of Science:

  • Pharmacology
  • Respiratory Medicine

Background:

  • Theophylline is a bronchodilator with additional beneficial effects for asthma patients, including mediator release inhibition and enhanced mucociliary clearance.
  • Individual variability in theophylline pharmacodynamics is observed in asthmatic patients.

Purpose of the Study:

  • To review the pharmacodynamic effects of theophylline in asthma.
  • To discuss the relationship between serum theophylline concentrations and bronchodilatory response.
  • To explore the implications of drug administration timing for controlled-release theophylline therapy.

Main Methods:

  • Literature review of studies on theophylline's effects in asthma.
  • Analysis of pharmacodynamic data relating serum concentrations to therapeutic responses.
  • Discussion of chronopharmacological principles for theophylline dosing.

Main Results:

  • Most of theophylline's bronchodilatory effect occurs at serum concentrations between 0-10 mg/liter, with lesser effects up to 20 mg/liter.
  • Pharmacodynamic relationships for non-bronchodilatory effects are less established.
  • Nighttime or early morning peak serum concentrations may enhance theophylline's benefits due to circadian variations in airway function.

Conclusions:

  • Theophylline possesses multiple therapeutic actions beneficial for asthma management.
  • Understanding the concentration-response relationship is crucial for optimizing theophylline therapy.
  • Timing of controlled-release theophylline administration, targeting nighttime or early morning peaks, may improve therapeutic outcomes in asthma.

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