Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How much theophylline is enough?

R D Fairshter1

  • 1Department of Medicine, University of California, Irvine.

The American Journal of Medicine
|July 29, 1988
PubMed
Summary
This summary is machine-generated.

Theophylline offers bronchodilation and other benefits for asthma. Optimal therapeutic effects, including bronchodilation, are achieved at specific serum theophylline concentrations, with nighttime dosing potentially maximizing benefits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of age on changes in flow rates and airway conductance after a deep breath.

Journal of applied physiology (Bethesda, Md. : 1985)·1990
Same author

Long-term survival of a lung cancer patient treated with photodynamic therapy.

Lasers in surgery and medicine·1990
Same author

Effects of thoracic gas compression on maximal and partial flow-volume maneuvers.

Journal of applied physiology (Bethesda, Md. : 1985)·1989
Same author

The MVV/FEV1 ratio in normal and asthmatic subjects.

Chest·1989
Same author

Effect of dimethylthiourea on plasma paraquat concentration.

Toxicology·1988
Same author

Adverse effects of (15S)-15-methyl-prostaglandin E1 in normal and paraquat-exposed rats.

Toxicology and applied pharmacology·1988
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric Panniculitis.

The American journal of medicine·2026
Same journal

Hypercalcemia and hyperferritinemia in a patient with Graves' disease disease.

The American journal of medicine·2026
See all related articles

Area of Science:

  • Pharmacology
  • Respiratory Medicine

Background:

  • Theophylline is a bronchodilator with additional beneficial effects for asthma patients, including mediator release inhibition and enhanced mucociliary clearance.
  • Individual variability in theophylline pharmacodynamics is observed in asthmatic patients.

Purpose of the Study:

  • To review the pharmacodynamic effects of theophylline in asthma.
  • To discuss the relationship between serum theophylline concentrations and bronchodilatory response.
  • To explore the implications of drug administration timing for controlled-release theophylline therapy.

Main Methods:

  • Literature review of studies on theophylline's effects in asthma.
  • Analysis of pharmacodynamic data relating serum concentrations to therapeutic responses.
  • Discussion of chronopharmacological principles for theophylline dosing.

Related Experiment Videos

Main Results:

  • Most of theophylline's bronchodilatory effect occurs at serum concentrations between 0-10 mg/liter, with lesser effects up to 20 mg/liter.
  • Pharmacodynamic relationships for non-bronchodilatory effects are less established.
  • Nighttime or early morning peak serum concentrations may enhance theophylline's benefits due to circadian variations in airway function.

Conclusions:

  • Theophylline possesses multiple therapeutic actions beneficial for asthma management.
  • Understanding the concentration-response relationship is crucial for optimizing theophylline therapy.
  • Timing of controlled-release theophylline administration, targeting nighttime or early morning peaks, may improve therapeutic outcomes in asthma.