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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
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Circulating Level of Monocyte Chemoattractant Protein-1 and Risk of Coronary Artery Disease: A Case-Control and

Jing Li1, Yanqun Zhang1, Xue Guo1

  • 1Department of Health Care, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, 271100, People's Republic of China.

Pharmacogenomics and Personalized Medicine
|May 19, 2021
PubMed

Insights

Elevated monocyte chemoattractant protein-1 (MCP1) levels are linked to a higher risk of coronary artery disease (CAD). This finding suggests MCP1 may play a role in the development of this leading cause of death.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Genetics

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Inflammation is recognized as a key factor in all stages of CAD and atherogenesis.
  • Monocyte chemoattractant protein-1 (MCP1) is a critical regulator of monocyte migration.

Purpose of the Study:

  • To investigate the association between CAD risk and genetic predisposition to circulating MCP1 levels.
  • To explore the role of MCP1 in the pathophysiology of coronary artery disease.

Main Methods:

  • A case-control study was conducted to assess the relationship between MCP1 levels and CAD risk.
  • A two-sample Mendelian randomization (MR) study was employed to examine the causal effect of genetically predicted MCP1 levels on CAD risk.
  • Sensitivity analyses, including MR Egger intercept tests, were performed to ensure the robustness of the findings and assess pleiotropy.

Main Results:

  • The case-control study revealed a significant association between higher circulating MCP1 levels and increased CAD risk (OR per quartile: 1.33).
  • Mendelian randomization analysis indicated that genetically predicted higher MCP1 levels were significantly associated with a higher risk of CAD (OR per 1-SD increase: 1.05).
  • Sensitivity analyses confirmed the main findings and found no evidence of directional pleiotropy.

Conclusions:

  • The study suggests a significant association between an increased predisposition to higher MCP1 levels and elevated risk of coronary artery disease.
  • Further research is warranted to fully elucidate the contribution of MCP1 to the pathogenesis of CAD.
Abstract

Keywords:
MCP1Mendelian randomizationcase–controlcoronary artery disease

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