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Optic pathway gliosarcoma: A very rare location for a rare disease
Renato Masson de Almeida Prado1, Bruno Pierri Tamura1, Gustavo Dalul Gomez1
1Department of Diagnostic Imaging, Division of Neuroradiology, Universidade Federal de São Paulo (UNIFESP), SP 04024-002, Brazil.
Radiology Case Reports
|May 19, 2021
Summary
Gliosarcoma is a rare central nervous system tumor. This case highlights its potential occurrence in the optic pathway, even in older adults, emphasizing the need for careful diagnosis.
Area of Science:
- Neuro-oncology
- Pathology
- Radiology
Background:
- Gliosarcoma, a rare glioblastoma variant, comprises glial and sarcomatous elements.
- Optic pathway gliosarcomas are exceptionally rare, with only two prior reported cases.
- This study focuses on a unique case of optic pathway gliosarcoma.
Observation:
- A 53-year-old male presented with headache, behavioral changes, and vision loss.
- MRI revealed an optic pathway lesion involving the chiasm and right optic nerve.
- Open brain biopsy and immunohistochemistry confirmed gliosarcoma.
Findings:
- Gliosarcoma diagnosis was confirmed via histopathology and immunohistochemistry.
- The tumor presented as an expansile lesion in the optic pathway.
- This represents a rare instance of gliosarcoma in this location.
Implications:
- Gliosarcoma should be considered in the differential diagnosis of optic pathway tumors, particularly in older patients.
- Accurate diagnosis relies on neuropathologist expertise.
- This case expands the understanding of rare CNS tumor presentations.
