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Endotoxin-induced increased alveolar capillary membrane permeability.

P Fischer, J E Millen, F L Glauser

    Circulatory Shock
    |January 1, 1977
    PubMed
    Summary

    Endotoxin acutely increases the permeability of the pulmonary alveolar capillary membrane (ACM) to molecules up to 10,400 MW. Larger molecules like albumin were unaffected, and histamine

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    Area of Science:

    • Pulmonary Physiology
    • Endotoxin Research
    • Capillary Permeability

    Background:

    • Endotoxin's effects on lung physiology are complex.
    • Understanding alveolar capillary membrane (ACM) permeability is crucial for respiratory health.

    Purpose of the Study:

    • To investigate the impact of endotoxin on ACM permeability.
    • To determine the molecular weight cutoff for endotoxin-induced permeability changes.

    Main Methods:

    • Utilized an in vivo dog lung model.
    • Measured the movement of various molecular weight solutes across the ACM post-endotoxin injection.
    • Analyzed histamine levels in lung liquid and blood.

    Main Results:

    • Endotoxin significantly increased ACM permeability for solutes up to 10,400 MW.
    • No significant permeability increase was observed for 20,000 MW dextran or albumin (69,000 MW).
    • Lung liquid histamine increased, but blood histamine did not, suggesting local effects.

    Conclusions:

    • Endotoxin acutely enhances ACM permeability for small to medium-sized molecules (up to 10,400 MW).
    • The precise role of histamine in this endotoxin-induced permeability increase requires further investigation.

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