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Updated: Nov 5, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Functionalizing DNA nanostructures for therapeutic applications.

Skylar J W Henry1, Nicholas Stephanopoulos1

  • 1School of Molecular Sciences, Biodesign Center for Molecular Design and Biomimetics, Arizona State University, Tempe, Arizona, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|May 19, 2021
PubMed
Summary
This summary is machine-generated.

DNA nanotechnology enables programmable nanostructures for biomedicine. Modifications enhance stability, cellular uptake, and targeted delivery, paving the way for advanced therapies.

Keywords:
DNA nanotechnologybiomaterialsdrug delivery

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Area of Science:

  • Nanotechnology
  • Biomedical Research
  • DNA Nanotechnology

Background:

  • Nanotechnology advances biomedical research in drug delivery, imaging, and sensing.
  • DNA nanotechnology utilizes self-assembling oligonucleotides for programmable nanostructures.
  • DNA nanostructures offer versatile platforms for biological applications due to their design flexibility.

Purpose of the Study:

  • To examine DNA nanostructure modifications and their functional outcomes.
  • To explore the potential of functionalized DNA nanostructures in biomedicine.
  • To identify barriers to the translational use of DNA nanostructures.

Main Methods:

  • Review of supramolecular and covalent modification strategies for DNA nanostructures.
  • Analysis of how modifications impact stability, cellular interactions, and cargo delivery.
  • Examination of stimulus-responsive behaviors and immune response modulation.

Main Results:

  • Modifications improve structural stability under physiological conditions.
  • Functionalized DNA nanostructures demonstrate enhanced cellular uptake and targeting.
  • Alterations enable the delivery of diverse molecular cargos and stimulus-responsive functions.

Conclusions:

  • DNA nanostructure modifications significantly expand their biomedical potential.
  • Functionalized DNA nanostructures hold promise for advanced therapeutic and diagnostic applications.
  • Overcoming translational barriers is crucial for clinical implementation.