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Related Experiment Videos

Isoflurane for conscious sedation.

M R Rodrigo1, J B Rosenquist

  • 1Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Hong Kong, Prince Philip Dental Hospital.

Anaesthesia
|May 1, 1988
PubMed
Summary
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Conscious sedation with isoflurane (0.5% in oxygen) was preferred by most patients undergoing wisdom tooth removal over placebo or nitrous oxide. This method ensured patient cooperation and rapid recovery without adverse effects.

Area of Science:

  • Anesthesiology
  • Oral Surgery
  • Pharmacology

Background:

  • Conscious sedation is crucial for patient comfort during outpatient surgical procedures.
  • Evaluating novel or alternative anesthetic agents for sedation is an ongoing area of research.
  • Nitrous oxide is a common agent for conscious sedation, but its efficacy and side effect profile are well-documented.

Purpose of the Study:

  • To compare the efficacy and patient acceptance of 0.5% isoflurane in oxygen for conscious sedation.
  • To compare isoflurane sedation against placebo (oxygen) and nitrous oxide in oxygen.
  • To assess the suitability of isoflurane for patients undergoing surgical removal of impacted lower third molars.

Main Methods:

  • A comparative study involving patients scheduled for bilateral, impacted lower third molar extraction.

Related Experiment Videos

  • Three sedation groups: 0.5% isoflurane in oxygen, placebo (oxygen), and equipotent nitrous oxide in oxygen.
  • Assessment of patient preference, operating conditions, vital signs, and adverse effects.

    • Main Results:

    • The majority of patients preferred 0.5% isoflurane in oxygen for conscious sedation.
    • Isoflurane provided good operating conditions with cooperative patients and did not significantly affect vital signs.
    • No significant intraoperative or postoperative adverse effects were reported with isoflurane.

    Conclusions:

    • 0.5% isoflurane in oxygen is a well-tolerated and preferred agent for conscious sedation in this patient group.
    • Isoflurane sedation facilitates cooperative patients and rapid recovery, with patients being street fit within 10 minutes post-operation.
    • Isoflurane offers a viable alternative to nitrous oxide for conscious sedation in oral surgery.