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Related Experiment Video

Updated: Nov 5, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study.

Adithya Gurumurthy1, Clement Kleinstreuer2

  • 1Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, NC 27695.

Journal of Biomechanical Engineering
|May 19, 2021
PubMed
Summary

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Analysis of improved oral drug delivery with different helical stream inhalation modes.

Computers in biology and medicine·2022
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Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region.

Computers in biology and medicine·2020
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Nanomedicine for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome.

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Modeling Airflow and Particle Deposition in a Human Acinar Region.

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Critical reviews in biomedical engineering·2018

Helical airflow enhances pulmonary nanodrug delivery by centralizing nanoparticles in the upper respiratory tract. This novel method improves deep lung deposition compared to conventional jets, reducing waste and toxicity.

Area of Science:

  • Pulmonary drug delivery
  • Nanoscience and nano-engineering
  • Computational fluid dynamics (CFD)

Background:

  • Rising prevalence of pulmonary diseases necessitates improved drug delivery systems.
  • Nanoscience enables potent, inhalable drug formulations for targeted pulmonary therapy.
  • Minimizing off-target deposition is crucial for efficacy and reducing toxicity.

Purpose of the Study:

  • To numerically analyze a novel helical airflow method for pulmonary nanotherapeutic delivery.
  • To compare the efficacy of helical streams versus axial jets for nanodrug transport.
  • To assess the impact of helical flow on nanoparticle deposition in the respiratory tract.

Main Methods:

  • Utilized a customized open-source computational fluid dynamics (CFD) toolbox, OpenFOAM.
Keywords:
openfoamCFDhelical drug-aerosol streamshuman upper respiratory tractimproved drug deliverynanoparticles

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  • Simulated helical air-nanoparticle streams within a human upper respiratory tract model.
  • Analyzed nanoparticle trajectory and deposition patterns under varying flow conditions.

    • Main Results:

    • Helical airflow centralizes nanoparticles, minimizing deposition in the oropharyngeal region.
    • Optimal helical streams (30 L/min) improved delivery of 300-nm particles beyond generation 3 by 5% compared to axial jets.
    • Helical flows demonstrated enhanced delivery to deeper lung regions.

    Conclusions:

    • Helical airflow is a robust methodology for improving pulmonary nanodrug delivery.
    • This approach enhances deep lung deposition and reduces off-target nanoparticle waste.
    • The findings support the clinical implementation of helical streams in nanotherapeutics.