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Targeted Thrombolytic Therapy with Metal-Organic-Framework-Derived Carbon Based Platforms with Multimodal
Yini Zhang1, Yu Liu2, Teng Zhang3
1the National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, P.R. China.
ACS Applied Materials & Interfaces
|May 19, 2021
Summary
This study introduces a dual-responsive nanoplatform for thrombolytic therapy, using urokinase plasminogen activators (uPA) loaded in MOF-derived carbon nanomaterials (CFs). The system effectively dissolves blood clots using near-infrared light and alternating magnetic fields for enhanced deep tissue treatment.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Thrombolytic therapy is crucial for treating blood clots.
- Existing therapies face limitations in targeting deep tissue and efficiency.
- Metal-organic framework (MOF)-derived carbon nanomaterials offer potential for drug delivery and theranostics.
Purpose of the Study:
- To develop a dual-responsive nanoplatform for enhanced thrombolytic therapy.
- To utilize MOF-derived carbon nanomaterials for targeted drug delivery and magnetic hyperthermia.
- To investigate the efficacy of the nanoplatform in treating deep venous thrombosis.
Main Methods:
- Fabrication of urokinase plasminogen activators (uPA)-loaded MOF-derived carbon nanomaterials (uPA@CFs).
- Utilizing near-infrared (NIR) irradiation for superficial thrombolysis via photothermy.
- Employing alternating magnetic field (AMF) for deep tissue thrombosis heating and targeted therapy.
- Quantitative assessment of thrombolytic efficiency in deep venous thrombosis models.
Main Results:
- The uPA@CFs system demonstrated dual-response capabilities for thrombolysis.
- NIR-mediated photothermy released uPA for superficial clot dissolution.
- AMF enabled precise heating of deep thrombosis, significantly enhancing thrombolysis.
- The dual-response system showed nearly a 6-fold increase in thrombolytic efficiency compared to NIR alone for deep venous thrombosis.
- MOF-derived carbon nanomaterials exhibited magnetic targeting ability and drug-carrying capacity.
- The developed nanomaterials also demonstrated angiogenic performance.
Conclusions:
- MOF-derived carbon nanomaterials serve as an effective platform for targeted thrombolysis.
- The dual-responsive uPA@CFs nanoplatform offers superior thrombolytic efficiency, especially for deep venous thrombosis.
- This novel approach shows promise for clinical applications in thrombolytic therapy due to its enhanced efficacy and angiogenic potential.
