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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Nov 5, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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TAP AND INJECT VERSUS PARS PLANA VITRECTOMY FOR POSTPROCEDURAL ENDOPHTHALMITIS: A Meta-analysis.

Parsa M Far1, Shanna C Yeung2, Pedram L Farimani2

  • 1Department of Ophthalmology, Queen's University, Kingston, Ontario, Canada.

Retina (Philadelphia, Pa.)
|May 19, 2021
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Summary
This summary is machine-generated.

Intravitreal antimicrobial injection is as effective as prompt pars plana vitrectomy (PPV) for treating endophthalmitis. Both treatments offer comparable visual outcomes for post-surgical and post-injection infections.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Surgical Outcomes

Background:

  • Endophthalmitis is a serious intraocular infection often occurring after eye surgery or injections.
  • Prompt treatment is crucial to preserve vision and prevent further complications.

Purpose of the Study:

  • To compare the visual outcomes of prompt pars plana vitrectomy (PPV) versus intravitreal antimicrobial injection for treating endophthalmitis.
  • To determine the noninferiority of intravitreal antimicrobial injection compared to PPV.

Main Methods:

  • A systematic review and meta-analysis of retrospective case series published between 2010 and 2020.
  • Data from 1,355 eyes were analyzed, comparing visual outcomes (improvement of ≥2 lines and logMAR) between PPV and intravitreal antimicrobial injection.
  • Methodological quality was assessed using the Cochrane ROBINS-I tool.

Main Results:

  • Fifteen retrospective case series involving 1,355 eyes were included.
  • No significant difference in visual outcome was observed between PPV and intravitreal antimicrobial injection.
  • The relative risk of improving ≥2 lines was 1.04 (PPV vs. injection) and the mean difference in logMAR improvement was 0.04, with no statistical significance.

Conclusions:

  • Intravitreal antimicrobial injection is noninferior to PPV for treating endophthalmitis.
  • This finding applies to endophthalmitis occurring after cataract surgery, injections, and PPV procedures.
  • Intravitreal antimicrobial injection represents a viable and effective initial treatment option.