Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.8K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.6K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.6K
Abnormal Proliferation02:23

Abnormal Proliferation

4.8K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

8.1K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.1K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.6K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manipulating Interfacial Water Molecules via Eutectic-Polymer Dual-Network for Stable Electrochromic Devices.

Angewandte Chemie (International ed. in English)·2026
Same author

Multifunctional Optoelectronic Logic Gates and Artificial Synapses Based on Coexistent Positive and Negative Photoconductivity SnSe<sub>2</sub> Photodetectors.

The journal of physical chemistry letters·2026
Same author

<b>The first new species of <i>Oxydromus</i> (Annelida: Hesionidae) from the China Seas</b>.

Zootaxa·2026
Same author

Adaptive Attentional Regulation to Emotional Faces in Subclinical Depression.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Epidemiological characteristics of monkeypox virus infection: a systematic review and meta-analysis.

BMC infectious diseases·2026
Same author

The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases.

Acta neuropathologica communications·2026

Related Experiment Video

Updated: Nov 5, 2025

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

9.9K

Collagen prolyl 4-hydroxylases modify tumor progression.

Run Shi1, Shanshan Gao1, Jie Zhang1

  • 1Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou 510095, China.

Acta Biochimica Et Biophysica Sinica
|May 19, 2021
PubMed
Summary

Collagen prolyl 4-hydroxylase (C-P4H) enzymes are crucial for collagen stability and are highly expressed in tumors. Targeting C-P4H shows promise for developing novel anti-cancer therapies.

Keywords:
P4HAsP4HBcancer progressioncollageninhibitors

More Related Videos

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
08:19

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Published on: April 22, 2019

7.3K
Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
10:24

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Published on: May 9, 2016

17.4K

Related Experiment Videos

Last Updated: Nov 5, 2025

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

9.9K
Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
08:19

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Published on: April 22, 2019

7.3K
Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
10:24

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Published on: May 9, 2016

17.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Collagen, the primary extracellular matrix component, requires proline hydroxylation for triple helix stability.
  • Collagen prolyl 4-hydroxylase (C-P4H) enzymes, comprising α (P4HA1-3) and β (P4HB) subunits, catalyze this essential hydroxylation.
  • Dysregulation of C-P4H subunits is implicated in various cancer types.

Purpose of the Study:

  • To review the regulatory mechanisms of C-P4H expression in cancer progression.
  • To summarize the role of C-P4H in tumor development.
  • To highlight the therapeutic potential of targeting C-P4H for cancer treatment.

Main Methods:

  • Literature review of studies on C-P4H function, expression, and regulation in cancer.
  • Analysis of the impact of cytokines, transcription factors, and microRNAs on P4HA and P4HB gene expression.
  • Evaluation of existing and potential therapeutic strategies targeting C-P4H.

Main Results:

  • C-P4H subunits (P4HAs and P4HB) are frequently overexpressed in numerous tumors.
  • C-P4H activity is linked to enhanced cancer cell proliferation, migration, and invasion.
  • Inhibitors of C-P4H have demonstrated significant anti-tumor effects in preclinical studies.

Conclusions:

  • C-P4H plays a critical role in promoting cancer progression through its involvement in collagen stabilization and extracellular matrix remodeling.
  • The overexpression and functional significance of C-P4H in tumors present a viable therapeutic target.
  • Targeting C-P4H offers a promising strategy for future cancer therapy development.