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Updated: Nov 5, 2025
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Pre-operative embolization for staged treatment of infantile choroid plexus papilloma
William M Mangham1, Lucas Elijovich1,2,3, Jorge A Lee-Diaz4,5
1Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA.
Insights
Choroid plexus papillomas (CPPs) are rare, benign brain tumors often found in young children. A staged approach using embolization before surgical resection can safely manage large CPPs, reducing surgical risks.
Area of Science:
- Neuro-oncology
- Pediatric Neurosurgery
Background:
- Choroid plexus papillomas (CPPs) are rare, benign neuroepithelial neoplasms.
- CPPs predominantly affect children under 5 years old and can cause hydrocephalus.
- Surgical resection is the standard treatment, but large tumors in infants pose significant risks, including excessive blood loss.
Abstract:
Choroid plexus papillomas (CPPs) are benign but rare neuroepithelial neoplasms of the choroid plexus that represent the non-malignant form of a spectrum of tumors of the choroid plexus. The vast majority of CPPs present in children under 5 years of age. Some CPPs are diagnosed prenatally, but many of them reach a large size before diagnosis. CPPs typically present with signs and symptoms of hydrocephalus. Treatment of these tumors has traditionally been with surgical resection. Large CPPs in young children present a challenge due to risk of high blood loss during resection. Here, the authors describe the case of a 3-month-old presenting with hydrocephalus and a large CPP of the third ventricle that was managed with a staged strategy of embolization followed by a delayed resection, allowing the tumor to involute prior to surgery.
