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Corneal involvement in Reye syndrome.

M J Krawitz¹, H D Perry

¹Nassau County Medical Center, East Meadow, New York.

Annals of Ophthalmology

|March 1, 1988

Summary

Reye syndrome, a condition typically lacking eye involvement, presented with unusual corneal stromal infiltration and pannus formation in a unique case. This finding expands the known spectrum of ocular complications associated with Reye syndrome.

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Area of Science:

Ophthalmology
Pediatric Neurology
Pathology

Background:

Reye syndrome is a rare but serious condition affecting children and teenagers, often triggered by viral infections and aspirin use.
Previous literature has extensively documented neurological and hepatic manifestations of Reye syndrome.
Ocular pathology has not been a recognized feature of Reye syndrome.

Observation:

A patient diagnosed with Reye syndrome exhibited significant ocular symptoms.
The observed ocular pathology included corneal stromal infiltration and pannus formation.
These specific ocular findings were not previously associated with Reye syndrome.

Findings:

This case report details the first known instance of corneal stromal infiltration and pannus formation in a patient with Reye syndrome.
The study highlights a novel correlation between Reye syndrome and specific anterior segment ocular abnormalities.
Histopathological examination may be warranted to further elucidate the pathogenesis of these ocular findings.

Implications:

The findings suggest that Reye syndrome may have a broader spectrum of clinical manifestations than previously understood.
Ophthalmologists should consider Reye syndrome in the differential diagnosis of unexplained corneal stromal infiltration and pannus.
Further research is needed to investigate the mechanisms linking Reye syndrome to ocular pathology and to determine the long-term visual prognosis.

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