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[Pharmacokinetic study of chloramphenicol in the rabbit]
P Guillot1, P Sanders, D Mourot
1Ministère de l'Agriculture, Laboratoire National des Médicaments Vétérinaires.
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1988
Abstract:
Chloramphenicol was administered intravenously and orally at a dose of 50 mg/kg to ten rabbits. Pharmacokinetic parameters were calculated (rate constant of terminal phase: beta = 0.21 +/- 0.09 1/h, total body clearance: Cl = 22.7 +/- 2.1 ml/min.kg, bioavailability: F = 42.5 +/- 11.9%) and were used to discuss the proposed dosage. However, caecotrophy might occur and increase absorption of chloramphenicol.