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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Gold-Catalyzed Access to Isophosphinoline 2-Oxides
Mina Hariri1,2, Fatemeh Darvish2, Karen-Pacelye Mengue Me Ndong1,3
1ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
Abstract:
Gold(I)-catalyzed reactions of electron-poor alkynes are still a challenging process. A straightforward synthesis of phosphorus-based heterocycles, namely, 2-phenyl 1H-isophosphinoline 2-oxides 1, is reported. The reaction used PPh3AuCl precatalyst in combination with triflic acid under microwave activation and afforded isophosphinoline 2-oxides 1 in moderate to quantitative yields through a fully regioselective 6-endo-dig hydroarylation cyclization, paving the way toward an effective synthesis of phosphorus heterocycles.
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