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Long-term outcomes of peripheral arterial disease patients with significant coronary artery disease undergoing

Byoung Geol Choi1, Ji-Yeon Hong2, Seung-Woon Rha3

  • 1Cardiovascular Research Institute, Korea University, Seoul, Korea.

Plos One
|May 19, 2021
PubMed

Insights

Routine coronary angiography in peripheral arterial disease patients undergoing angioplasty does not impact long-term survival. Evaluating coronary artery disease (CAD) in PAD patients is crucial for guiding treatment strategies and reducing mortality risk.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Peripheral arterial disease (PAD) patients face a high risk of cardiac mortality.
  • The benefit of routine coronary angiography (CAG) in PAD patients undergoing percutaneous transluminal angioplasty (PTA) remains unclear.

Purpose of the Study:

  • To evaluate the effectiveness of routine CAG in PAD patients undergoing PTA.
  • To assess the impact of coronary artery disease (CAD) on long-term outcomes in PAD patients.

Main Methods:

  • 765 PAD patients undergoing successful PTA were analyzed.
  • Patients were grouped based on routine CAG and presence/absence of CAD.
  • Multivariable Cox regression and propensity score matching (PSM) were used for analysis with 5-year follow-up.

Main Results:

  • 5-year survival rates were similar across groups (CAD, no CAD, no CAG).
  • PSM showed no significant differences in death, MI, stroke, or revascularization between CAD and no CAD groups.
  • Repeat PCI was higher in the CAD group (9.3%) compared to the no CAD group (0.8%).

Conclusions:

  • PAD patients with CAD do not have poorer long-term survival than those without CAD when treated appropriately.
  • Routine CAG followed by PCI, if indicated, is a reasonable strategy for mortality risk reduction in PAD patients.
  • Evaluating for CAD in PAD patients is essential for risk stratification and management.
Abstract

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