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Autonomic neuropathy in systemic sclerosis.

P S Klimiuk1, L Taylor, R D Baker

  • 1Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford.

Annals of the Rheumatic Diseases
|July 1, 1988
PubMed
Summary
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Systemic sclerosis patients show significant autonomic nervous system dysfunction, impacting cardiovascular reflexes. This autonomic neuropathy is a key feature in both diffuse and CREST variants of systemic sclerosis.

Area of Science:

  • Rheumatology
  • Neurology
  • Cardiology

Background:

  • Systemic sclerosis is a complex autoimmune disease affecting connective tissues.
  • Autonomic dysfunction is increasingly recognized as a complication in systemic sclerosis.
  • Cardiovascular reflex testing provides objective measures of autonomic function.

Purpose of the Study:

  • To investigate autonomic function using cardiovascular reflex tests in patients with systemic sclerosis.
  • To compare autonomic function in systemic sclerosis patients with primary Raynaud's phenomenon and healthy controls.
  • To determine if autonomic neuropathy is a characteristic feature of systemic sclerosis.

Main Methods:

  • Assessed autonomic function via cardiovascular reflex tests.
  • Included 25 patients with systemic sclerosis (CREST and diffuse variants).

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  • Included 10 patients with primary Raynaud's phenomenon and 13 healthy controls for comparison.

    • Main Results:

    • Systemic sclerosis patients exhibited significant abnormalities in cardiovascular reflexes.
    • Both CREST and diffuse systemic sclerosis variants showed autonomic dysfunction.
    • Evidence of sympathetic and parasympathetic nervous system impairment was observed.

    Conclusions:

    • Autonomic neuropathy is a significant feature of systemic sclerosis.
    • Cardiovascular reflex testing is valuable for detecting autonomic dysfunction in systemic sclerosis.
    • Findings highlight the systemic impact of sclerosis on autonomic regulation.