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Immunomodulatory nanosystems for treating inflammatory diseases.
Nadim Ahamad1, Abhinanda Kar1, Sourabh Mehta2
1Nanomedicine Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India.
Biomaterials
|May 19, 2021
Summary
Immunomodulatory nanosystems (IMNs) offer a novel approach to treating inflammatory diseases (IDs) by precisely modulating the immune system. These systems target hyperactive immune cells, addressing the root cause of inflammation for sustained relief.
Area of Science:
- Nanomedicine
- Immunology
- Materials Science
Background:
- Inflammatory diseases (IDs) present a significant global health and economic burden.
- Current therapies for IDs are palliative, offering only short-term symptom relief.
- There is a need for innovative treatments that address the underlying causes of chronic inflammation.
Purpose of the Study:
- To explore the potential of immunomodulatory nanosystems (IMNs) as a therapeutic strategy for inflammatory diseases.
- To discuss the mechanisms by which IMNs modulate the immune system.
- To highlight challenges and future directions in the application of IMNs for treating IDs.
Main Methods:
- Review of representative examples of IMNs.
- Discussion of IMN rationalization, design principles, and mechanisms of action.
- Analysis of IMN interactions with immune cells and inflamed tissues.
Main Results:
- IMNs can precisely modulate immune responses through seven distinct mechanisms, including cytokine modulation, cellular infiltration control, and macrophage polarization.
- The nano-sized nature of IMNs facilitates efficient delivery to inflamed sites and interaction with hyperactive immune cells.
- IMNs demonstrate potential in restoring immune homeostasis and alleviating inflammation.
Conclusions:
- IMNs represent a promising therapeutic avenue for inflammatory diseases, offering a potential to address underlying causes and prevent recurrence.
- Further research and overcoming technical challenges are crucial for the successful clinical application of IMNs.
- IMNs hold the potential to revolutionize the treatment of a wide range of inflammatory conditions.
Keywords:
Immuno-engineeringImmunomodulationImmunomodulatory-nanosystemsImmunotherapyInflammatory-diseasesTrigger-responsive-nanosystesmsMore Related Videos
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